Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC₅₀: 30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum

Product does not compete with ATP.

Primary Targetbasal soluble guanylyl cyclase

General description

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC₅₀ = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC₅₀ = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.

Warning

Toxicity: Standard Handling (A)